全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR00113G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Rad17 Antibody.
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分子量 |
77055 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
Rad17
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亞型 |
Rabbit IgG
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通用名 |
R24L
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基因ID |
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UniProt ID |
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功能 |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
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總結(jié) |
Rad17 is an essential component of cell cycle checkpoints activated by DNA damage and disruption of DNA replication. DNA lesions such as single- and double-strand breaks, inter- and intra-strand cross-links, and base modifications hamper transcription and replication, resulting in cell cycle arrest, apoptosis, and mutagenesis. Phosphorylation of Rad17 at Ser635 and Ser645 is a critical early event during checkpoint signaling in DNA damaged cells.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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說(shuō)明書 |
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數(shù)量 |
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