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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody

TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR00545G 7 ml / ¥4950

TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody

品牌

Leading Biology

貨號(hào)

APR00545G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody.

分子量

30kDa

細(xì)胞定位

Antigen Cellular Localization: Secreted, extracellular space, extracellular matrix

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse, Rat, Cow, Horse, Dog

亞型

Rabbit / IgG

基因ID

UniProt ID

功能

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

總結(jié)

TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.

形式

Liquid

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

IHC-P, IF, FC

圖像

Formalin-fixed, paraffin-embedded human Placenta stained with TIMP3 Rabbit Polyclonal Antibody.

說明書

數(shù)量

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