MAPK10 Antibody (N-term)

APR05859G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05859G		100 μl / ￥4950

大規(guī)格詢價(jià)

2 Images

訂購信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國授權(quán)代理商

MAPK10 Antibody (N-term)

品牌	Leading Biology	貨號	APR05859G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAPK10 Antibody (N-term).
分子量	52585 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity).
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	7-34 aa
靶點(diǎn)	This MAPK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human MAPK10.
亞型	Rabbit Ig
通用名	JNK3, JNK3A, PRKM10, SAPK1B
基因ID	5602
UniProt ID	P53779
功能	Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
總結(jié)	MAPK10 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	IHC-P~~1:25 WB~~1:1000
圖像	Immunohistochemical analysis of paraffin-embedded H. pancreas section using MAPK10 Antibody (N-term)( APR05859G). APR05859G was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining. MAPK10 Antibody (C21) (Cat. APR05859G) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPK10 antibody detected the MAPK10 protein (arrow).
說明書	Product Datasheet Protocol
數(shù)量

加入購物車詢價(jià)

上一產(chǎn)品：MAPK14 Antibody (Y323) 下一產(chǎn)品：Phospho-mouse TSC1(S594) Antibody

熱銷產(chǎn)品

產(chǎn)品添加成功！

購物車已有 0 件產(chǎn)品

繼續(xù)訂購查看訂購單

加入詢價(jià)單成功！

詢價(jià)單已有 0 件產(chǎn)品

繼續(xù)詢價(jià) 查看詢價(jià)單

選擇	品牌	貨號	產(chǎn)品名稱	規(guī)格	分類	研究領(lǐng)域	說明書	數(shù)量	目錄價(jià)
1	Leading Biology	APR05963G	EGFR Antibody (Y1092)	100 μl	Polyclonal Antibodies				￥4950.00	訂購詢價(jià)
2	Leading Biology	APR03116G	BRCA1 Antibody (aa1847-1863)	100 μl	Polyclonal Antibodies				￥4950.00	訂購詢價(jià)
3	Leading Biology	AMM05633G	Bombesin Receptor 2 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購詢價(jià)
4	Leading Biology	APR10986G	AP3B1 Antibody (aa2-14)	50 μg	Polyclonal Antibodies				￥4950.00	訂購詢價(jià)
5	Leading Biology	APR11512G	Bestrophin-1 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購詢價(jià)
6	Leading Biology	APG01407G	A3 Adenosine Receptor Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購詢價(jià)

最新加入的商品

最新加入的商品

全部產(chǎn)品分類