Phospho-ERBB3(Y1289) Antibody

APR05230G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR05230G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Phospho-ERBB3(Y1289) Antibody

品牌	Leading Biology	貨號(hào)	APR05230G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-ERBB3(Y1289) Antibody.
分子量	148098 Da
細(xì)胞定位	Antigen Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.
亞型	Rabbit Ig
通用名	HER3
基因ID	2065
UniProt ID	P21860
功能	Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
總結(jié)	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, DB, E
稀釋方法	DB~~1:500 WB~~1:1000
圖像	Dot blot analysis of anti-Phospho-ERBB3 (Tyr1289) Antibody Phospho-specific Pab (Cat. APR05230G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Western blot analysis of extracts from T47D cells,untreated or treated with NRG using Phospho-ErBB3(Tyr1289)(left) or ErBB3 antibody(right).
說(shuō)明書(shū)	Product Datasheet Protocol
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