KLF4 Antibody (N-term)

APR05059G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR05059G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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KLF4 Antibody (N-term)

品牌	Leading Biology	貨號	APR05059G
產(chǎn)品分類	Polyclonal Antibodies	研究領域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLF4 Antibody (N-term).
分子量	54671 Da
細胞定位	Antigen Cellular Localization: Nucleus.
宿主	Rabbit
種屬反應性	Human
免疫原	20-53 aa
靶點	This KLF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-53 amino acids from the N-terminal region of human KLF4.
亞型	Rabbit Ig
通用名	EZF, GKLF
基因ID	9314
UniProt ID	O43474
功能	Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
總結	Kruppel-like factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the colon. It is down-regulated in both mouse and human colonic adenomas and has been implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem cells. KLF4 can act as a transcriptional activator or repressor, but the underlying mechanisms are poorly understood.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, E
稀釋方法	WB~~1:1000
圖像	KLF4 Antibody (N-term) (Cat. APR05059G) western blot analysis in Hela,MCF-7,SW480 cell line lysates (35ug/lane).This demonstrates the KLF4 antibody detected the KLF4 protein (arrow).
說明書	Product Datasheet Protocol
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