ZRANB1 Antibody (C-term)

APR06203G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR06203G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ZRANB1 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR06203G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZRANB1 Antibody (C-term).
分子量	80967 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	665-692 aa
靶點(diǎn)	This ZRANB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 665-692 amino acids from the C-terminal region of human ZRANB1.
亞型	Rabbit Ig
通用名	TRABID
基因ID	54764
UniProt ID	Q9UGI0
功能	Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
總結(jié)	ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100
圖像	Western blot analysis of ZRANB1 Antibody (C-term) (Cat. APR06203G) in K562 cell line lysates (35ug/lane). ZRANB1 (arrow) was detected using the purified Pab. Western blot analysis of ZRANB1 Antibody (C-term) (Cat. APR06203G) in mouse cerebellum tissue lysates (35ug/lane). ZRANB1 (arrow) was detected using the purified Pab. ZRANB1 Antibody (C-term) (Cat. APR06203G) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZRANB1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
說(shuō)明書(shū)	Product Datasheet Protocol
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