品牌 |
Leading Biology | 貨號(hào) |
APR06089G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PEA-15 Antibody (C-term).
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分子量 |
15040 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Note=Associated with microtubules
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
86-115 aa
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靶點(diǎn) |
This PEA-15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the C-terminal region of human PEA-15.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
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總結(jié) |
PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, FC, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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圖像 |
Western blot analysis of PEA-15 Antibody (C-term) (Cat. APR06089G) in T47D cell line lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab. Western blot analysis of PEA-15 Antibody (C-term) (Cat. APR06089G) in mouse lung tissue lysates (35ug/lane).PEA-15 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded mouse heart tissue reacted with PEA-15 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
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說(shuō)明書(shū) |
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數(shù)量 |
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