ALOX5AP Antibody (Center)

APR06025G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR06025G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ALOX5AP Antibody (Center)

品牌	Leading Biology	貨號	APR06025G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ALOX5AP Antibody (Center).
分子量	18157 Da
細胞定位	Antigen Cellular Localization: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	86-117 aa
靶點	This ALOX5AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-117 amino acids from the Central region of human ALOX5AP.
亞型	Rabbit Ig
通用名	FLAP
基因ID	241
UniProt ID	P20292
功能	Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
總結(jié)	ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
圖像	Western blot analysis of anti-ALOX5AP Antibody (Center) (Cat.APR06025G) in K562 cell line lysates (35ug/lane). ALOX5AP(arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ALOX5AP antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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