VINC Antibody (N-term)

APR05906G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR05906G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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VINC Antibody (N-term)

品牌	Leading Biology	貨號	APR05906G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality VINC Antibody (N-term).
分子量	123799 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity) Colocalizes with LIMD1 in the focal adhesions.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
免疫原	12-39 aa
靶點(diǎn)	This VINC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human VINC.
亞型	Rabbit Ig
基因ID	7414
UniProt ID	P18206
功能	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
總結(jié)	VINC is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
圖像	All lanes : Anti-VINC Antibody (N-term) at 1:2000 dilution Lane 1: RD whole cell lysates Lane 2: Hela whole cell lysates Lane 3: rat liver lysates Lane 4: human testis lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 124 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Western blot analysis of anti-VINC Antibody (N-term) (Cat.APR05906G) in K562 cell line lysates (35ug/lane). VINC (arrow) was detected using the purified Pab. Western blot analysis of anti-VINC Antibody (N-term) (Cat.APR05906G) in mouse lung tissue lysates (35ug/lane). VINC (arrow) was detected using the purified Pab.
說明書	Product Datasheet Protocol
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