CASC3 Antibody (Y181)

APR05872G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05872G		100 μl / ￥4950

大規(guī)格詢價(jià)

2 Images

訂購(gòu)信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國(guó)授權(quán)代理商

CASC3 Antibody (Y181)

品牌	Leading Biology	貨號(hào)	APR05872G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CASC3 Antibody (Y181).
分子量	76278 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Note=Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	159-188 aa
靶點(diǎn)	This CASC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-188 amino acids from human CASC3.
亞型	Rabbit Ig
通用名	MLN51
基因ID	22794
UniProt ID	O15234
功能	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.
總結(jié)	Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
圖像	Anti-CASC3 Antibody (Y181) at 1:1000 dilution + NCI-H460 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CASC3 Antibody (Y181) (Cat.APR05872G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說(shuō)明書	Product Datasheet Protocol
數(shù)量

加入購(gòu)物車詢價(jià)

上一產(chǎn)品：NAE1 (APPBP1) Antibody (C-term) 下一產(chǎn)品：CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody - With BSA and Azide

熱銷產(chǎn)品

產(chǎn)品添加成功！

購(gòu)物車已有 0 件產(chǎn)品

繼續(xù)訂購(gòu) 查看訂購(gòu)單

加入詢價(jià)單成功！

詢價(jià)單已有 0 件產(chǎn)品

繼續(xù)詢價(jià) 查看詢價(jià)單

選擇	品牌	貨號(hào)	產(chǎn)品名稱	規(guī)格	分類	研究領(lǐng)域	說(shuō)明書	數(shù)量	目錄價(jià)
1	Leading Biology	APR05963G	EGFR Antibody (Y1092)	100 μl	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢價(jià)
2	Leading Biology	APR03116G	BRCA1 Antibody (aa1847-1863)	100 μl	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢價(jià)
3	Leading Biology	AMM05633G	Bombesin Receptor 2 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢價(jià)
4	Leading Biology	APR10986G	AP3B1 Antibody (aa2-14)	50 μg	Polyclonal Antibodies				￥4950.00	訂購(gòu) 詢價(jià)
5	Leading Biology	APR11512G	Bestrophin-1 (extracellular) Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢價(jià)
6	Leading Biology	APG01407G	A3 Adenosine Receptor Antibody	50 μl	Polyclonal Antibodies				￥6950.00	訂購(gòu) 詢價(jià)

最新加入的商品

最新加入的商品

全部產(chǎn)品分類