RAN Antibody (N-term)

APR05788G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05788G		100 μl / ￥4950

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RAN Antibody (N-term)

品牌	Leading Biology	貨號(hào)	APR05788G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RAN Antibody (N-term).
分子量	24423 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity) Becomes dispersed throughout the cytoplasm during mitosis Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	12-39 aa
靶點(diǎn)	This RAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human RAN.
亞型	Rabbit Ig
通用名	ARA24
基因ID	5901
UniProt ID	P62826
功能	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
總結(jié)	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, FC, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50
圖像	Western blot analysis of RAN Antibody (N-term) (Cat. APR05788G) in HL-60 cell line lysates (35ug/lane).RAN (arrow) was detected using the purified Pab. Western blot analysis of RAN antibody (N-term) (Cat. APR05788G) in NIH-3T3 cell line lysates (35ug/lane). RAN (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human brain tissue reacted with RAN Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說(shuō)明書(shū)	Product Datasheet Protocol
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