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當(dāng)前位置：首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > MTBP Antibody (C-term)

MTBP Antibody (C-term)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR05780G 100 μl / ￥4950

MTBP Antibody (C-term)

品牌

 Leading Biology

貨號(hào)

 APR05780G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MTBP Antibody (C-term).

分子量
102193 Da

宿主
Rabbit

種屬反應(yīng)性
Human

免疫原
853-881 aa

靶點(diǎn)
This MTBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 853-881 amino acids from the C-terminal region of human MTBP.

亞型
Rabbit Ig

基因ID

UniProt ID

功能
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

總結(jié)
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, FC, E

稀釋方法
WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50

圖像

Western blot analysis of MTBP antibody (C-term) (Cat. APR05780G) in K562 cell line lysates (35ug/lane). MTBP (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with MTBP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Flow cytometric analysis of K562 cells using MTBP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

說明書

數(shù)量

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