Phospho-IKKB(S689) Antibody

APR05265G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05265G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Phospho-IKKB(S689) Antibody

品牌	Leading Biology	貨號(hào)	APR05265G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-IKKB(S689) Antibody.
分子量	86564 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	This IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S689 of human IKKB.
亞型	Rabbit Ig
通用名	IKKB
基因ID	3551
UniProt ID	O14920
功能	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
總結(jié)	NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivateNF-kappa-B by trapping it in the cytoplasm. Phosphorylation ofserine residues on the I-kappa-B proteins by kinases (IKBKA, MIM600664, or IKBKB) marks them for destruction via the ubiquitinationpathway, thereby allowing activation of the NF-kappa-B complex.Activated NFKB complex translocates into the nucleus and binds DNAat kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	DB, E
稀釋方法	DB~~1:500
圖像	Dot blot analysis of Phospho-IKKB-S689 Antibody Phospho-specific Pab (Cat. APR05265G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
說(shuō)明書	Product Datasheet Protocol
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