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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-CRK(S41) Antibody

Phospho-CRK(S41) Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR05165G 100 μl / ￥4950

Phospho-CRK(S41) Antibody

品牌

 Leading Biology

貨號(hào)

 APR05165G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-CRK(S41) Antibody.

分子量
33831 Da

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.

宿主
Rabbit

種屬反應(yīng)性
Human

靶點(diǎn)
This CRK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S41 of human CRK.

亞型
Rabbit Ig

基因ID

UniProt ID

功能
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

總結(jié)
CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
DB, E

稀釋方法
DB~~1:500

圖像

Dot blot analysis of Phospho-CRK-S41 polyclonal antibody ( APR05165G) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-Pab: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide.

說(shuō)明書

數(shù)量

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