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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-CDC25A(S75) Antibody

Phospho-CDC25A(S75) Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR05105G 100 μl / ￥4950

Phospho-CDC25A(S75) Antibody

品牌

 Leading Biology

貨號(hào)

 APR05105G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-CDC25A(S75) Antibody.

分子量
59087 Da

宿主
Rabbit

種屬反應(yīng)性
Human

靶點(diǎn)
This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S75 of human CDC25A.

亞型
Rabbit Ig

基因ID

UniProt ID

功能
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

總結(jié)
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, E

稀釋方法
WB~~1:1000 IHC-P~~1:50~100

圖像

The anti-Phospho-CDC25A-S75 Pab (Cat. APR05105G) is used in Western blot to detect Phospho-CDC25A-S75 in, form left to right, Hela, HL60, mouse kidney, and mouse liver tissue lysates.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

說(shuō)明書(shū)

數(shù)量

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