TRAIP Antibody (C-term)

APR05083G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR05083G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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TRAIP Antibody (C-term)

品牌	Leading Biology	貨號	APR05083G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRAIP Antibody (C-term).
分子量	53294 Da
細胞定位	Antigen Cellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	328-356 aa
靶點	This TRAIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-356 amino acids from the C-terminal region of human TRAIP.
亞型	Rabbit Ig
通用名	RNF206, TRIP
基因ID	10293
UniProt ID	Q9BWF2
功能	Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.
總結(jié)	TRAIP is a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
圖像	Western blot analysis of anti-TRAIP Antibody (C-term) (Cat.APR05083G) in HepG2 cell line lysates (35ug/lane). TRAIP(arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TRAIP antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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