LGR5 (GPR49) Antibody (loop1)

APR05064G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR05064G		100 μl / ￥4950

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LGR5 (GPR49) Antibody (loop1)

品牌	Leading Biology	貨號(hào)	APR05064G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LGR5 (GPR49) Antibody (loop1).
分子量	99998 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	605-638 aa
靶點(diǎn)	This LGR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-638 amino acids from human LGR5.
亞型	Rabbit Ig
通用名	GPR49, GPR67
基因ID	8549
UniProt ID	O75473
功能	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
總結(jié)	LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:10~50 WB~~1:1000
圖像	Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (loop1) (Cat.APR05064G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. LGR5/GPR49 Antibody (loop1) (APR05064G) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow).
說明書	Product Datasheet Protocol
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