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當(dāng)前位置：首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > MUC4(Mucin-4 alpha chain) Antibody (N-term)

MUC4(Mucin-4 alpha chain) Antibody (N-term)

貨號 貨期 規(guī)格 / 價格 詢價
APR04696G 100 μl / ￥4950

MUC4(Mucin-4 alpha chain) Antibody (N-term)

品牌

 Leading Biology

貨號

 APR04696G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MUC4(Mucin-4 alpha chain) Antibody (N-term).

分子量
231518 Da

細(xì)胞定位
Antigen Cellular Localization: Membrane; Single-pass membrane protein. Secreted Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing Mucin-4 alpha chain: Secreted. Isoform 11: Secreted. Isoform 17: Cell membrane; Single-pass membrane protein

宿主
Rabbit

種屬反應(yīng)性
Human

靶點
This MUC4(Mucin-4 alpha chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human MUC4(Mucin-4 alpha chain).

亞型
Rabbit Ig

基因ID

UniProt ID

功能
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

總結(jié)
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

儲存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, E

稀釋方法
WB~~1:1000

圖像

Western blot analysis of lysates from Hela, MCF-7 cell line (from left to right), using MUC4(Mucin-4 alpha chain) Antibody (N-term)(APR04696G). APR04696G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

說明書

數(shù)量

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