全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04523G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality F13B Antibody (N-term).
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分子量 |
75511 Da
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細胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
151-179 aa
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靶點 |
This F13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-179 amino acids from the N-terminal region of human F13B.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
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總結(jié) |
This gene encodes coagulation factor XIII B subunit.Coagulation factor XIII is the last zymogen to become activated inthe blood coagulation cascade. Plasma factor XIII is aheterotetramer composed of 2 A subunits and 2 B subunits. The Asubunits have catalytic function, and the B subunits do not haveenzymatic activity and may serve as a plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which areidentical to those of plasma origin. Upon activation by thecleavage of the activation peptide by thrombin and in the presenceof calcium ion, the plasma factor XIII dissociates its B subunitsand yields the same active enzyme, factor XIIIa, as platelet factorXIII. This enzyme acts as a transglutaminase to catalyze theformation of gamma-glutamyl-epsilon-lysine crosslinking betweenfibrin molecules, thus stabilizing the fibrin clot. Factor XIIIdeficiency is classified into two categories: type I deficiency,characterized by the lack of both the A and B subunits; and type IIdeficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defectivewound healing, and habitual abortion.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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