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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR04518G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL28RA Antibody (C-term).
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分子量 |
57653 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
485-513 aa
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靶點(diǎn) |
This IL28RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 485-513 amino acids from the C-terminal region of human IL28RA.
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亞型 |
Rabbit Ig
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通用名 |
IL28RA, LICR2
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基因ID |
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UniProt ID |
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功能 |
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
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總結(jié) |
The protein encoded by this gene belongs to the class IIcytokine receptor family. This protein forms a receptor complexwith interleukine 10 receptor, beta (IL10RB). The receptor complexhas been shown to interact with three closely related cytokines,including interleukin 28A (IL28A), interleukin 28B (IL28B), andinterleukin 29 (IL29). The expression of all three cytokines can beinduced by viral infection. The cells overexpressing this proteinhave been found to have enhanced responses to IL28A and IL29, butdecreased response to IL28B. Three alternatively spliced transcriptvariants encoding distinct isoforms have been reported. [providedby RefSeq].
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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