PPM1F Antibody (Center)

APR04499G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR04499G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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PPM1F Antibody (Center)

品牌	Leading Biology	貨號(hào)	APR04499G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PPM1F Antibody (Center).
分子量	49831 Da
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	275-303 aa
靶點(diǎn)	This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.
亞型	Rabbit Ig
通用名	KIAA0015, POPX2
基因ID	9647
UniProt ID	P49593
功能	Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
總結(jié)	The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.This phosphatase can interact with Rho guanine nucleotide exchangefactors (PIX), and thus block the effects of p21-activated kinase 1(PAK), a protein kinase mediating biological effects downstream ofRho GTPases. Calcium/calmodulin-dependent protein kinase II gamma(CAMK2G/CAMK-II) is found to be one of the substrates of thisphosphatase. The overexpression of this phosphatase or CAMK2G hasbeen shown to mediate caspase-dependent apoptosis. An alternativelyspliced transcript variant has been identified, but its full-lengthnature has not been determined.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	PPM1F Antibody (Center) (Cat. APR04499G) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PPM1F antibody detected the PPM1F protein (arrow).
說(shuō)明書(shū)	Product Datasheet Protocol
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