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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APR04479G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NR3C1 Antibody (C-term).
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分子量 |
85659 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
560-588 aa
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靶點(diǎn) |
This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-588 amino acids from the C-terminal region of human NR3C1.
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亞型 |
Rabbit Ig
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通用名 |
GRL
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基因ID |
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UniProt ID |
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功能 |
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
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總結(jié) |
The protein encoded by this gene is a receptor forglucocorticoids that can act as both a transcription factor and asa regulator of other transcription factors. This protein can alsobe found in heteromeric cytoplasmic complexes along with heat shockfactors and immunophilins. The protein is typically found in thecytoplasm until it binds a ligand, which induces transport into thenucleus. Mutations in this gene are a cause of glucocorticoidresistance, or cortisol, resistance. Alternate splicing, the use ofat least three different promoters, and alternate translationinitiation sites result in several transcript variants encoding thesame protein or different isoforms, but the full-length nature ofsome variants has not been determined.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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