品牌 |
Leading Biology | 貨號 |
APR04460G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MKRN1 Antibody(Center).
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分子量 |
53349 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
184-213 aa
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靶點 |
This MKRN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the Central region of human MKRN1.
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亞型 |
Rabbit Ig
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通用名 |
RNF61
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基因ID |
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UniProt ID |
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功能 |
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
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總結(jié) |
The Makorin ring finger protein-1 gene (MKRN1) is a highlytranscribed, intron-containing source for a family of intronlessmammalian genes encoding a novel class of zinc finger proteins.Phylogenetic analyses indicate that the MKRN1 gene is the ancestralfounder of this gene family (Gray et al., 2000 [PubMed10843807]).
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
MKRN1 Antibody (Center) (Cat. APR04460G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the MKRN1 antibody detected the MKRN1 protein (arrow). |
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說明書 |
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數(shù)量 |
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