全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04439G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAET1E Antibody(Center).
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分子量 |
30122 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
150-179 aa
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靶點 |
This RAET1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human RAET1E.
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亞型 |
Rabbit Ig
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通用名 |
LETAL, N2DL4, ULBP4
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基因ID |
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UniProt ID |
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功能 |
Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
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總結(jié) |
Members of the RAET1 family, such as RAET1E, are majorhistocompatibility complex (MHC) class I-related genes locatedwithin a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteinscontain MHC class I-like alpha-1 and alpha-2 domains. RAET1E andRAET1G (MIM 609244) differ from the other RAET1 proteins (e.g.,RAET1I, or ULBP1; MIM 605697) in that they have type Imembrane-spanning sequences at their C termini rather thanglycosylphosphatidylinositol anchor sequences. RAET1E is a ligandfor NKG2D (KLRK1; MIM 611817), which is expressed on the surface ofseveral types of immune cells and is involved in innate andadaptive immune responses (summary by Radosavljevic et al. (2002)[PubMed 11827464] and Cao et al. (2007) [PubMed17470428]).
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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