全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04410G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PSMD14 Antibody (C-term).
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分子量 |
34577 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
258-287 aa
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靶點 |
This PSMD14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from the C-terminal region of human PSMD14.
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亞型 |
Rabbit Ig
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通用名 |
POH1
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基因ID |
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UniProt ID |
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功能 |
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
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總結(jié) |
PSMD14 is a component of the 26S proteasome, amultiprotein complex that degrades proteins targeted fordestruction by the ubiquitin pathway (Spataro et al., 1997 [PubMed9374539]).
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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