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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > RNF111 Antibody (N-term)

RNF111 Antibody (N-term)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR04326G 100 μl / ¥4950

RNF111 Antibody (N-term)

品牌

Leading Biology

貨號(hào)

APR04326G

產(chǎn)品分類(lèi)

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RNF111 Antibody (N-term).

分子量

108862 Da

細(xì)胞定位

Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol

宿主

Rabbit

種屬反應(yīng)性

Human

免疫原

209-237 aa

靶點(diǎn)

This RNF111 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human RNF111.

亞型

Rabbit Ig

基因ID

UniProt ID

功能

Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.

總結(jié)

The protein encoded by this gene contains a RING fingerdomain, a motif known to be involved in protein-protein andprotein-DNA interactions. The mouse counterpart of this gene(Rnf111/arkadia) has been shown to genetically interact with thetransforming growth factor (TGF) beta-like factor Nodal, and act asa modulator of the nodal signaling cascade, which is essential forthe induction of mesoderm during embryonic development. [providedby RefSeq].

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, E

稀釋方法

WB~~1:1000

圖像

RNF111 Antibody (N-term) (Cat. APR04326G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RNF111 antibody detected the RNF111 protein (arrow).

說(shuō)明書(shū)

數(shù)量

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