品牌 |
Leading Biology |
貨號 |
APR04287G |
產(chǎn)品分類 |
Polyclonal Antibodies |
研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CCR4 Antibody (C-term).
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分子量 |
41403 Da
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
262-290 aa
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靶點 |
This CCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the C-terminal region of human CCR4.
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亞型 |
Rabbit Ig
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通用名 |
CMKBR4
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基因ID |
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UniProt ID |
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功能 |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
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總結(jié) |
The protein encoded by this gene belongs to theG-protein-coupled receptor family . It is a receptor for the CCchemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a groupof small polypeptide, structurally related molecules that regulatecell trafficking of various types of leukocytes. The chemokinesalso play fundamental roles in the development, homeostasis, andfunction of the immune system, and they have effects on cells ofthe central nervous system as well as on endothelial cells involvedin angiogenesis or angiostasis.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
CCR4 Antibody (C-term) (Cat. APR04287G) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CCR4 antibody detected the CCR4 protein (arrow).
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說明書 |
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數(shù)量 |
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