FBLN5 Antibody (C-term)

APR04273G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR04273G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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FBLN5 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR04273G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FBLN5 Antibody (C-term).
分子量	50180 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	393-421 aa
靶點(diǎn)	This FBLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-421 amino acids from the C-terminal region of human FBLN5.
亞型	Rabbit Ig
通用名	DANCE
基因ID	10516
UniProt ID	Q9UBX5
功能	Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823).
總結(jié)	The protein encoded by this gene is a secreted,extracellular matrix protein containing an Arg-Gly-Asp (RGD) motifand calcium-binding EGF-like domains. It promotes adhesion ofendothelial cells through interaction of integrins and the RGDmotif. It is prominently expressed in developing arteries but lessso in adult vessels. However, its expression is reinduced inballoon-injured vessels and atherosclerotic lesions, notably inintimal vascular smooth muscle cells and endothelial cells.Therefore, the protein encoded by this gene may play a role invascular development and remodeling. Defects in this gene are acause of autosomal dominant cutis laxa, autosomal recessive cutislaxa type I (CL type I), and age-related macular degeneration type3 (ARMD3).
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	FBLN5 Antibody (C-term) (Cat. APR04273G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FBLN5 antibody detected the FBLN5 protein (arrow).
說(shuō)明書	Product Datasheet Protocol
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