RASSF1 Antibody (Center)

APR04256G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR04256G		100 μl / ￥4950

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RASSF1 Antibody (Center)

品牌	Leading Biology	貨號(hào)	APR04256G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RASSF1 Antibody (Center).
分子量	39219 Da
細(xì)胞定位	Antigen Cellular Localization: Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells Colocalizes with MDM2 in the nucleus
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	103-132 aa
靶點(diǎn)	This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.
亞型	Rabbit Ig
基因ID	11186
UniProt ID	Q9NS23
功能	Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
總結(jié)	This gene encodes a protein similar to the RAS effectorproteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, whichsuggests the tumor suppressor function of this gene. Theinactivation of this gene was found to be correlated with thehypermethylation of its CpG-island promoter region. The encodedprotein was found to interact with DNA repair protein XPA. Theprotein was also shown to inhibit the accumulation of cyclin D1,and thus induce cell cycle arrest. Seven alternatively splicedtranscript variants of this gene encoding distinct isoforms havebeen reported.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	Anti-RASSF1 Antibody (Center) at 1:2000 dilution + KG-1 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST. RASSF1 Antibody (Center) (Cat. APR04256G) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the RASSF1 antibody detected the RASSF1 protein (arrow).
說(shuō)明書	Product Datasheet Protocol
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