品牌 |
Leading Biology | 貨號 |
APR04194G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GPNMB Antibody (C-term).
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分子量 |
63923 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
541-569 aa
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靶點 |
This GPNMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human GPNMB.
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亞型 |
Rabbit Ig
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通用名 |
HGFIN, NMB
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基因ID |
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UniProt ID |
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功能 |
Could be a melanogenic enzyme.
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總結(jié) |
The protein encoded by this gene is a type I transmembraneglycoprotein which shows homology to the pMEL17 precursor, amelanocyte-specific protein. GPNMB shows expression in the lowlymetastatic human melanoma cell lines and xenografts but does notshow expression in the highly metastatic cell lines. GPNMB may beinvolved in growth delay and reduction of metastatic potential. Twotranscript variants encoding different isoforms have been found forthis gene.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:500
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圖像 |
Anti-GPNMB Antibody (C-term) at 1:500 dilution + PC-3 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 64 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
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說明書 |
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數(shù)量 |
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