SIGLEC6 Antibody (C-term)

APR04086G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR04086G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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SIGLEC6 Antibody (C-term)

品牌	Leading Biology	貨號	APR04086G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIGLEC6 Antibody (C-term).
分子量	49913 Da
細(xì)胞定位	Antigen Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
免疫原	381-412 aa
靶點	This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human SIGLEC6.
亞型	Rabbit Ig
通用名	CD33L, CD33L1, OBBP1
基因ID	946
UniProt ID	O43699
功能	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
總結(jié)	SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P, WB, E
稀釋方法	IHC-P~~1:50~100 WB~~1:1000
圖像	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. The anti-Siglec6 C-term Pab (Cat. APR04086G) is used in Western blot to detect Siglec6 in mouse spleen tissue lysate. SIGLEC6 Antibody (Cat. APR04086G) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SIGLEC6 antibody detected the SIGLEC6 protein (arrow).
說明書	Product Datasheet Protocol
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