全部產品分類
品牌 |
Leading Biology | 貨號 |
APR04071G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LOXL2 Antibody (C-term).
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分子量 |
86725 Da
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細胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus. Chromosome Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
589-617 aa
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靶點 |
This LOXL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-617 amino acids from the C-terminal region of human LOXL2.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
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總結 |
This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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