品牌 |
Leading Biology | 貨號 |
APR04021G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HBEGF Antibody (Center).
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分子量 |
23067 Da
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細胞定位 |
Antigen Cellular Localization:
Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
68-96 aa
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靶點 |
This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the Central region of human HBEGF.
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亞型 |
Rabbit Ig
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通用名 |
DTR, DTS, HEGFL
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基因ID |
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UniProt ID |
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功能 |
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
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總結 |
HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
HBEGF Antibody (Center) (Cat. APR04021G) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HBEGF antibody detected the HBEGF protein (arrow). |
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說明書 |
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數量 |
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