全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR04014G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality A2M Antibody (C-term).
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分子量 |
163291 Da
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細胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
1162-1192 aa
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靶點 |
This A2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1162-1192 amino acids from the C-terminal region of human A2M.
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亞型 |
Rabbit Ig
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通用名 |
CPAMD5
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基因ID |
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UniProt ID |
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功能 |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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總結(jié) |
Alpha-2-macroglobulin is a protease inhibitor and cytokinetransporter. It inhibits many proteases, including trypsin,thrombin and collagenase. A2M is implicated in Alzheimer disease(AD) due to its ability to mediate the clearance and degradation ofA-beta, the major component of beta-amyloid deposits. [provided byRefSeq].
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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