Mouse Clk2 Antibody (N-term)

APR03983G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR03983G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Mouse Clk2 Antibody (N-term)

品牌	Leading Biology	貨號	APR03983G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Clk2 Antibody (N-term).
分子量	59987 Da
細胞定位	Antigen Cellular Localization: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-141 results in accumulation in the nuclear speckle
宿主	Rabbit
種屬反應(yīng)性	Mouse
免疫原	66-93 aa
靶點	This Mouse Clk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the N-terminal region of mouse Clk2.
亞型	Rabbit Ig
基因ID	12748
UniProt ID	O35491
功能	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
總結(jié)	Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
圖像	Anti-Clk2 Antibody (N-term)at 1:1000 dilution + mouse cerebellum lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Western blot analysis of lysate from mouse spleen tissue lysate, using Clk2 Antibody (N-term)(APR03983G). APR03983G was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug. Mouse Clk2 Antibody (N-term) (Cat. APR03983G) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Clk2 antibody detected the Clk2 protein (arrow).
說明書	Product Datasheet Protocol
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