品牌 |
Leading Biology | 貨號(hào) |
APR03977G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MEOX1 Antibody (Center).
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分子量 |
27997 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus {ECO:0000250|UniProtKB:P32442}. Cytoplasm {ECO:0000250|UniProtKB:P32442}. Note=Localizes predominantly in the nucleus. {ECO:0000250|UniProtKB:P32442}
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
136-165 aa
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靶點(diǎn) |
This MEOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human MEOX1.
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亞型 |
Rabbit Ig
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通用名 |
MOX1
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基因ID |
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UniProt ID |
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功能 |
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
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總結(jié) |
This gene encodes a member of a subfamily ofnon-clustered, diverged, antennapedia-like homeobox-containinggenes. The encoded protein may play a role in the molecularsignaling network regulating somite development. Alternativelyspliced transcript variants encoding different isoforms have beendescribed.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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圖像 |
Anti-MEOX1 Antibody (Center) at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST. MEOX1 Antibody (Center) (Cat. APR03977G) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MEOX1 antibody detected the MEOX1 protein (arrow). Western blot analysis of MEOX1 (arrow) using rabbit polyclonal MEOX1 Antibody (Center) (Cat. APR03977G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MEOX1 gene. |
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說明書 |
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數(shù)量 |
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