全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR03881G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPM1D Antibody (Center).
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分子量 |
66675 Da
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
183-212 aa
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靶點 |
This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
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亞型 |
Rabbit Ig
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通用名 |
WIP1
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基因ID |
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UniProt ID |
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功能 |
Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
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總結(jié) |
The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.The expression of this gene is induced in a p53-dependent manner inresponse to various environmental stresses. While being induced bytumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through whichit reduces the phosphorylation of p53, and in turn suppressesp53-mediated transcription and apoptosis. This phosphatase thusmediates a feedback regulation of p38-p53 signaling thatcontributes to growth inhibition and the suppression of stressinduced apoptosis. This gene is located in a chromosomal regionknown to be amplified in breast cancer. The amplification of thisgene has been detected in both breast cancer cell line and primarybreast tumors, which suggests a role of this gene in cancerdevelopment.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說明書 |
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數(shù)量 |
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