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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR03817G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality JPH2 Antibody (C-term).
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分子量 |
74222 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity).
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
614-643 aa
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靶點(diǎn) |
This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.
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亞型 |
Rabbit Ig
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通用名 |
JP2
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基因ID |
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UniProt ID |
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功能 |
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
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總結(jié) |
Junctional complexes between the plasma membrane andendoplasmic/sarcoplasmic reticulum are a common feature of allexcitable cell types and mediate cross talk between cell surfaceand intracellular ion channels. The protein encoded by this gene isa component of junctional complexes and is composed of a C-terminalhydrophobic segment spanning the endoplasmic/sarcoplasmic reticulummembrane and a remaining cytoplasmic domain that shows specificaffinity for the plasma membrane. This gene is a member of thejunctophilin gene family. Alternative splicing has been observed atthis locus and two variants encoding distinct isoforms aredescribed.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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圖像 |
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說(shuō)明書 |
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數(shù)量 |
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