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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APR03741G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FKTN Antibody (Center).
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分子量 |
53724 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Golgi apparatus membrane; Single-pass type II membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
177-206 aa
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靶點(diǎn) |
This FKTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human FKTN.
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亞型 |
Rabbit Ig
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通用名 |
FCMD
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基因ID |
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UniProt ID |
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功能 |
Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development.
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總結(jié) |
The protein encoded by this gene is a putativetransmembrane protein that is localized to the cis-Golgicompartment, where it may be involved in the glycosylation ofalpha-dystroglycan in skeletal muscle. The encoded protein isthought to be a glycosyltransferase and could play a role in braindevelopment. Defects in this gene are a cause of Fukuyama-typecongenital muscular dystrophy (FCMD), Walker-Warburg syndrome(WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilatedcardiomyopathy type 1X (CMD1X). Alternatively spliced transcriptvariants have been found for this gene.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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