CDKN2B Antibody (N-term)

APR03719G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR03719G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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CDKN2B Antibody (N-term)

品牌	Leading Biology	貨號	APR03719G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDKN2B Antibody (N-term).
分子量	14722 Da
細胞定位	Antigen Cellular Localization: Cytoplasm. Note=Also found in the nucleus
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	1-30 aa
靶點	This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDKN2B.
亞型	Rabbit Ig
通用名	MTS2
基因ID	1030
UniProt ID	P42772
功能	Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
總結(jié)	This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, FC, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50 FC~~1:10~50
圖像	Western blot analysis of CDKN2B (arrow) using rabbit polyclonal CDKN2B Antibody (N-term) (Cat. APR03719G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CDKN2B gene. CDKN2B Antibody (N-term) (Cat. APR03719G)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CDKN2B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Confocal immunofluorescent analysis of CDKN2B Antibody (N-term)( APR03719G) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
說明書	Product Datasheet Protocol
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