全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR03646G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AXIN1 Antibody (C-term).
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分子量 |
95635 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Membrane. Cell membrane. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
710-738 aa
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靶點 |
This AXIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 710-738 amino acids from the C-terminal region of human AXIN1.
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亞型 |
Rabbit Ig
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通用名 |
AXIN
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基因ID |
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UniProt ID |
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功能 |
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
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總結(jié) |
This gene encodes a cytoplasmic protein which contains aregulation of G-protein signaling (RGS) domain and a dishevelledand axin (DIX) domain. The encoded protein interacts withadenomatosis polyposis coli, catenin beta-1, glycogen synthasekinase 3 beta, protein phosphate 2, and itself. This proteinfunctions as a negative regulator of the wingless-type MMTVintegration site family, member 1 (WNT) signaling pathway and caninduce apoptosis. The crystal structure of a portion of thisprotein, alone and in a complex with other proteins, has beenresolved. Mutations in this gene have been associated withhepatocellular carcinoma, hepatoblastomas, ovarian endometriodadenocarcinomas, and medullablastomas. Two transcript variantsencoding distinct isoforms have been identified for this gene.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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圖像 |
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說明書 |
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數(shù)量 |
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