全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR03641G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRADD Antibody (Center).
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分子量 |
34247 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
126-151 aa
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靶點(diǎn) |
This TRADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human TRADD.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
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總結(jié) |
The protein encoded by this gene is a death domaincontaining adaptor molecule that interacts with TNFRSF1A/TNFR1 andmediates programmed cell death signaling and NF-kappaB activation.This protein binds adaptor protein TRAF2, reduces the recruitmentof inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thussuppresses TRAF2 mediated apoptosis. This protein can also interactwith receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and isinvolved in the Fas-induced cell death pathway. [provided byRefSeq].
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, FC, IF, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
IF~~1:10~50
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圖像 |
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說明書 |
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數(shù)量 |
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