全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR03599G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KNG1 Antibody (N-term).
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分子量 |
71957 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
138-166 aa
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靶點(diǎn) |
This KNG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human KNG1.
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亞型 |
Rabbit Ig
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通用名 |
BDK, KNG
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基因ID |
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UniProt ID |
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功能 |
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.
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總結(jié) |
This gene uses alternative splicing to generate twodifferent proteins- high molecular weight kininogen (HMWK) and lowmolecular weight kininogen (LMWK). HMWK is essential for bloodcoagulation and assembly of the kallikrein-kinin system. Also,bradykinin, a peptide causing numerous physiological effects, isreleased from HMWK. In contrast to HMWK, LMWK is not involved inblood coagulation. Three transcript variants encoding differentisoforms have been found for this gene.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, FC, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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圖像 |
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說明書 |
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數(shù)量 |
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