品牌 |
Leading Biology | 貨號(hào) |
APR03594G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Parp9 Antibody (C-term).
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分子量 |
96659 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity).
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse
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免疫原 |
599-629 aa
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靶點(diǎn) |
This Parp9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-629 amino acids from the C-terminal region of human Parp9.
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亞型 |
Rabbit Ig
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通用名 |
Bal
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基因ID |
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UniProt ID |
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功能 |
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity).
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總結(jié) |
PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:50~100
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圖像 |
All lanes : Anti-Parp9 Antibody (C-term) at 1:1000 dilution Lane 1: mouse lung lysate Lane 2: mouse thymus lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 97 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Parp9 Antibody (C-term) (Cat. APR03594G)immunohistochemistry analysis in formalin fixed and paraffin embedded human lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Parp9 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
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說明書 |
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數(shù)量 |
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