全部產品分類
品牌 |
Leading Biology | 貨號 |
APR03531G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TNFR-S274 Antibody.
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分子量 |
50495 Da
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
252-281 aa
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靶點 |
This TNFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from human TNFR.
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亞型 |
Rabbit Ig
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通用名 |
TNFAR, TNFR1
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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總結 |
The protein encoded by this gene is a member of theTNF-receptor superfamily. This protein is one of the majorreceptors for the tumor necrosis factor-alpha. This receptor canactivate NF-kappaB, mediate apoptosis, and function as a regulatorof inflammation. Antiapoptotic protein BCL2-associated athanogene 4(BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown tointeract with this receptor, and thus play regulatory roles in thesignal transduction mediated by the receptor. Germline mutations ofthe extracellular domains of this receptor were found to beassociated with the autosomal dominant periodic fever syndrome. Theimpaired receptor clearance is thought to be a mechanism of thedisease.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, FC, E
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稀釋方法 |
WB~~1:1000
FC~~1:10~50
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圖像 |
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說明書 |
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數量 |
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