ANAPC5 Antibody (Center)

APR03506G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR03506G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ANAPC5 Antibody (Center)

品牌	Leading Biology	貨號	APR03506G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANAPC5 Antibody (Center).
分子量	85077 Da
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	156-185 aa
靶點	This ANAPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5.
亞型	Rabbit Ig
通用名	APC5
基因ID	51433
UniProt ID	Q9UJX4
功能	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
總結(jié)	This gene encodes a tetratricopeptide repeat-containingcomponent of the anaphase promoting complex/cyclosome (APC/C), alarge E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclinsfor 26S proteasome-mediated degradation through ubiquitination. Theencoded protein is required for the proper ubiquitination functionof APC/C and for the interaction of APC/C with transcriptioncoactivators. It also interacts with polyA binding protein andrepresses internal ribosome entry site-mediated translation.Multiple transcript variants encoding different isoforms have beenfound for this gene. These differences cause translation initiationat a downstream AUG and result in a shorter protein (isoform b),compared to isoform a.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, FC, E
稀釋方法	WB~~1:1000 FC~~1:10~50
圖像	ANAPC5 Antibody (Center) (Cat. APR03506G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ANAPC5 antibody detected the ANAPC5 protein (arrow). ANAPC5 Antibody (Center) (Cat. APR03506G) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
說明書	Product Datasheet Protocol
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