PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide

AMM05506G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM05506G		50 μg / ￥3950

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PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide

品牌	Leading Biology	貨號	AMM05506G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PGP9.5 / UchL1 (pan-Neuronal Marker) antibody - With BSA and Azide.
分子量	20-30kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Rat
靶點	Native UchL1 (PGP9.5) protein from brain
克隆號	31A3
亞型	IgG1, kappa
基因ID	7345
UniProt ID	P09936
功能	Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
總結(jié)	This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
形式	0.5 ml at 200ug/ml with BSA and azide
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC, IP, E
別名	Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, 6---, Neuron cytoplasmic protein 95, PGP 95, PGP95, Ubiquitin thioesterase L1, UCHL1
圖像	Formalin-fixed, paraffin-embedded human brain stained with Pgp9.5 / UchL1 Ab (31A3). Western blot of UchL1 (PGP9.5) in 1) human, 2) mouse and 3) rat brain lysate using UchL1 Ab (31A3).
說明書	Product Datasheet Protocol
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PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide