Bcl-X (Apoptosis Marker) Antibody - With BSA and Azide

APR07271G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR07271G		50 μg / ￥3950

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Bcl-X (Apoptosis Marker) Antibody - With BSA and Azide

品牌	Leading Biology	貨號	APR07271G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bcl-X (Apoptosis Marker) antibody - With BSA and Azide.
分子量	27kDa
細胞定位	Antigen Cellular Localization: Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
宿主	Mouse
種屬反應性	Human, Mouse, Rat, Pig
靶點	A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein
克隆號	2H12
亞型	IgG2a
通用名	BCL2L, BCLX
基因ID	598
UniProt ID	Q07817
功能	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis.
總結(jié)	Recognizes a protein of 27kDa, identified as the Bcl-X protein. This MAb shows no cross-reaction with Bcl-2? or Bax protein. Bcl-X has two isoforms, Bcl-XL (long), a 241 amino acid protein which suppresses cell death. And Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain which functions as a dominant inhibitor of Bcl-2. This MAb reacts with both Bcl-XS and Bcl-XL proteins.
形式	0.5 ml at 200ug/ml with BSA and azide
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC, IF, FC, IP, E
別名	Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L1, BCL2L, BCLX
圖像	Formalin-fixed, paraffin-embedded humanHodgkin's lymphoma stained with Bcl-x Ab (2H12). Note cytoplasmic and membrane staining. Western blot analysis of Jurkat Cell lysate using Bcl-X Ab (2H12).
說明書	Product Datasheet Protocol
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Bcl-X (Apoptosis Marker) Antibody - With BSA and Azide