ORAI3 Antibody [2H2G9]

APR17685G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17685G		0.1 mg / ￥6950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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ORAI3 Antibody [2H2G9]

品牌	Leading Biology	貨號(hào)	APR17685G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ORAI3 antibody [2H2G9] .
分子量	31499 Da
細(xì)胞定位	Antigen Cellular Localization: Membrane; Multi-pass membrane protein
宿主	Mouse
種屬反應(yīng)性	Human, Rat
靶點(diǎn)	ORAI3;
克隆號(hào)	2H2G9
亞型	IgG2a
通用名	TMEM142C
基因ID	93129
UniProt ID	Q9BRQ5
功能	Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.
總結(jié)	ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
圖像	Western blot analysis of ORAI3 in rat spleen lysate with ORAI3 antibody at 2 μg/mL. Immunohistochemistry of ORAI3 in rat spleen tissue with ORAI3 antibody at 2.5 μg/mL. Immunofluorescence of ORAI3 in rat spleen tissue with ORAI3 antibody at 5 μg/mL.
說(shuō)明書	Product Datasheet Protocol
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