Glutathione Peroxidase 4 Antibody (Clone 1H11)

AMRa00028G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMRa00028G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Glutathione Peroxidase 4 Antibody (Clone 1H11)

品牌	Leading Biology	貨號(hào)	AMRa00028G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Glutathione Peroxidase 4 antibody (Clone 1H11).
分子量	22175 Da
細(xì)胞定位	Antigen Cellular Localization: Isoform Mitochondrial: Mitochondrion.
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	Glutathione Peroxidase 4
克隆號(hào)	Clone 1H11
亞型	Mouse IgG1
基因ID	2879
UniProt ID	P36969
功能	Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
總結(jié)	Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	E, IP
別名	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GPX4
圖像	IP analysis of HL60 cell lysates. Lane 1: Input, Lane 2: Precipitated sample
說(shuō)明書(shū)	Product Datasheet Protocol
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Glutathione Peroxidase 4 Antibody (Clone 1H11)